Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

G Fehringer; P Kraft; PD Pharoah; RA Eeles; N Chatterjee; FR Schumacher; JM Schildkraut; S Lindström; P Brennan; H Bickeböller; RS Houlston; MT Landi; N Caporaso; A Risch; AA Al Olama; SI Berndt; EL Giovannucci; H Grönberg; Z Kote-Jarai; J Ma; K Muir; MJ Stampfer; VL Stevens; F Wiklund; WC Willett; EL Goode; JB Permuth; HA Risch; BM Reid; S Bezieau; H Brenner; AT Chan; J Chang-Claude; TJ Hudson; JK Kocarnik; PA Newcomb; RE Schoen; ML Slattery; E White; MA Adank; H Ahsan; K Aittomäki; L Baglietto; C Blomquist; F Canzian; K Czene; I Dos-Santos-silva; AH Eliassen; JD Figueroa; D Flesch-Janys; O Fletcher; M Garcia-Closas; MM Gaudet; N Johnson; P Hall; A Hazra; R Hein; A Hofman; JL Hopper; A Irwanto; M Johansson; R Kaaks; MG Kibriya; P Lichtner; J Liu; E Lund; E Makalic; A Meindl; B Müller-Myhsok; TA Muranen; H Nevanlinna; PH Peeters; J Peto; RL Prentice; N Rahman; MJ Sanchez; DF Schmidt; RK Schmutzler; MC Southey; R Tamimi; RC Travis; C Turnbull; AG Uitterlinden; Z Wang; AS Whittemore; XR Yang; W Zheng; DD Buchanan; G Casey; DV Conti; CK Edlund; S Gallinger; RW Haile; M Jenkins; L Marchand; L Li; NM Lindor; SL Schmit; SN Thibodeau; MO Woods

Journal article

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

G Fehringer, P Kraft, PD Pharoah, RA Eeles, N Chatterjee, FR Schumacher, JM Schildkraut, S Lindström, P Brennan, H Bickeböller, RS Houlston, MT Landi, N Caporaso, A Risch, AA Al Olama, SI Berndt, EL Giovannucci, H Grönberg, Z Kote-Jarai, J Ma Show all

Cancer Research | Published : 2016

DOI: 10.1158/0008-5472.CAN-15-2980

Abstract

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with..

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